Edited by Thomas Forbes. Edited by Wilbert S.
Edited by Lucio Cagini. Edited by Bishnu Pal.
How a prosthesis in aortic valve replacement is chosen
Published: December 22nd DOI: Jheleznev Open access peer-reviewed 3. Chen Open access peer-reviewed 7. Zheleznev Open access peer-reviewed 9. Furlanetto Open access peer-reviewed Edited Volume and chapters are indexed in. Open access peer-reviewed 1. Open access peer-reviewed 2.
Open access peer-reviewed 3. Open access peer-reviewed 4. Open access peer-reviewed 5.
Book Subject Areas
Open access peer-reviewed 6. Open access peer-reviewed 7. Open access peer-reviewed 8. Objective: Allograft heart valves are commonly used in cardiac surgery. Despite mounting evidence that these valves are immunogenic, leading to premature failure, current clinical practice does not attempt to minimize or control such a response. The objective of this study was to evaluate immune modulatory approaches to ameliorate allograft valve failure in a rat model.
Cardiac Valve Allografts II: Science and Practice - كتب Google
At 7 and 28 days the valves were examined for structural integrity and cellular infiltration. Twenty-eight days after implantation, daily treatment with cyclosporine preserved leaflet structural integrity and inhibited cellular infiltration. However, a short course of cyclosporine 7 days failed to prevent destruction of the valves at 28 days.
Conclusions: Immune modulatory approaches aimed at T-cell activation or trafficking decrease leaflet cellular infiltration and prevent allograft valve structural failure.
Related Cardiac Valve Allografts: Science and Practice
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